Sildenafil is one of the most widely prescribed PDE5 inhibitors for erectile dysfunction. With a well-established safety profile and rapid onset of action (30–60 minutes), it remains a first-line therapy for many patients seeking reliable support for sexual function.


Sildenafil selectively inhibits PDE5, the enzyme responsible for degrading cGMP in the corpus cavernosum. By preserving cGMP levels, it enhances nitric oxide–mediated vasodilation and penile blood flow during sexual arousal.
Common side effects include headache, flushing, visual disturbances, and nasal congestion. Absolutely contraindicated with nitrate medications. Patients should report any sudden vision or hearing changes immediately.
Speak with a licensed clinician to find out if Sildenafil is right for your protocol.
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